11β-Hydroxysteroid Dehydrogenase in the Dahl Rat
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چکیده
منابع مشابه
Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2
Zearalenone is a mycotoxin produced by Fusarium spp. 11β-Hydroxysteroid dehydrogenases, isoforms 1 (HSD11B1) and 2 (HSD11B2), have been demonstrated to be the regulators of the local level of active glucocorticoid, which has a broad range of physiological actions. In the present study, the potency of zearalenone was tested for the inhibition of HSD11B1 and HSD11B2 in rat and human tissues. Zear...
متن کامل11β-Hydroxysteroid Dehydrogenase Type 1 and the Metabolic Syndrome
In the past few years, efforts are being made to unravel the mechanisms endowed with the metabolic disturbances associated with obesity that predispose to the metabolic syndrome (MetSyn). The special pathogenic role of liver and visceral adipose tissue (VAT) functions has been particularly intriguing, and many hypotheses have been advanced to explain this association. Tissue-specific actions of...
متن کاملModulation of 11β-hydroxysteroid dehydrogenase 1 by β2-adrenoceptor in the ischaemia-reperfused rat kidney.
BACKGROUND 11β-Hydroxysteroid dehydrogenase Type 1 (11βHSD-1) amplifies intracellular levels of active glucocorticoids which possess protective effects against organ ischaemia and reperfusion (I/R). However, the mechanisms by which 11βHSD-1 is modified after a renal I/R challenge remain unclear. This study investigated the effect of β(2)-adrenoceptor (β(2)-AR) activation and the subsequent sign...
متن کامل11β-Hydroxysteroid Dehydrogenase-2 and Salt-Sensitive Hypertension.
1335 Glucocorticoid intracellular metabolism, catalyzed by the 2 isozymes of 11β-hydroxysteroid dehydrogenase (11βHSD), determines the corticosteroid action on target tissues. 11β-HSD1 functions as a reductase in most cells and catalyzes the regeneration of active glucocorticoids, thereby amplifying their action. This isozyme is widely expressed in liver, adipose tissue, muscle, pancreatic isle...
متن کاملPlacental 11 -Hydroxysteroid Dehydrogenase in Dahl and Spontaneously Hypertensive Rats
Studies in normotensive rats showed that excessive fetal exposure to maternal glucocorticoids retards growth and programs hypertension in later life. This excessive exposure is proposed to occur due to a reduction of the placental barrier to maternal glucocorticoids that is provided by 11 -hydroxysteroid dehydrogenase (11 HSD). To assess the possible alterations of glucocorticoid placental barr...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1997
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(97)00122-2